About EXPAREL®

EXPAREL: significant long-lasting pain control while reducing the need for opioids1,2
  • EXPAREL is indicated for single-dose infiltration in adults to produce postsurgical local analgesia and as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia
  • DepoFoam®drug delivery system slowly delivers bupivacaine over time to extend the pharmacologic effect of EXPAREL1,2
  • EXPAREL significantly reduces opioid consumption1,3,*
  • EXPAREL eliminates the need for catheters and pumps that may hinder recovery3-10
  • EXPAREL has a proven safety and tolerability profile


 *The clinical benefit of the decrease in opioid consumption was not demonstrated in the pivotal trials.

To learn more, visit www.EXPAREL.com

References

  • 1. Data on file. Parsippany, NJ: Pacira Pharmaceuticals, Inc.; May 2016.
  • 2. How DepoFoam® works. Pacira Pharmaceuticals, Inc. website. http://www.pacira.com/depofoam-platform/how-it-works.php. Accessed May 26, 2016.
  • 3. Gorfine SR, Onel E, Patou G, Krivokapic ZV. Bupivacaine extended-release liposome injection for prolonged postsurgical analgesia in patients undergoing hemorrhoidectomy: a multicenter, randomized, double-blind, placebo-controlled trial. Dis Colon Rectum. 2011;54(12):1552-1559.
  • 4. Kessler ER, Shah M, Gruschkus SK, Raju A. Cost and quality implications of opioid-based postsurgical pain control using administrative claims data from a large health system: opioid-related adverse events and their impact on clinical and economic outcomes. Pharmacotherapy.2013;33(4):383-391.
  • 5. Ilfeld BM, Loland VJ, Sandhu NS, Suresh PJ, Bishop MJ, Donohue MC. Continuous femoral nerve blocks: the impact of catheter tip location relative to the femoral nerve (anterior versus posterior) on quadriceps weakness and cutaneous sensory block. Anesth Analg. 2012;115(3):721-727.
  • 6. Kinder R, Hsiung R. Overview of peripheral nerve blocks. In: Chu LF, Fuller A, eds. Manual of Clinical Anesthesiology. 1st ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2011.
  • 7. Process for handling elastomeric pain relief balls (ON-Q PainBuster and others) requires safety improvements. Institute for Safe Medication Practices website. https://www.ismp.org/newsletters/acutecare/articles/20090716.asp. Accessed May 26, 2016.
  • 8. I-Flow ON-Q pump with ONDEMAND bolus button class I recall of risk of continuous infusion at a ration greater than expected. US Food and Drug Administration website. http://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanmedicalproducts/ucm317851.htm. Accessed May 26, 2016.
  • 9. Continuous peripheral nerve blocks in outpatients. NYSORA–The New York School of Regional Anesthesia website. http://www.nysora.com/mobile/regional-anesthesia/foundations-of-ra/3055-continuous-peripheral-nerve-blocks-in-outpatients.html. Accessed May 26, 2016.
  • 10. Frost & Sullivan. New Opportunities for Hospitals to Improve Economic Efficiency and Patient Outcomes: The Case of EXPAREL™, a long-acting, non-opioid local analgesic. http://www.frost.com/prod/servlet/cpo/252218999. Accessed May 26, 2016.